Temperature-controllable thermotherapeutic embolize micro-sphere and preparation method thereof

温度可控热疗栓塞微球及其制备方法

Abstract

本发明涉及一种温度可控制热疗栓塞微球,磁响应微粒分散于高分子材料形成的交联网络中;热疗栓微球剂的粒径在50μm-2000μm之间,磁响应微粒占整个栓塞微球的重量比为0.5-45%。本发明所述的制备方法,包括以下几个步骤:a:将合金材料加入到高分子材料的溶液中,混合均匀,形成含磁高分子溶液;b:搅拌下,将含磁高分子溶液加入分散相中;c:制得磁响应聚合物微球;d:过滤,洗涤,制备成磁响应微球的混悬液;e:制备干燥的磁响应聚合物微球。本发明的有益效果如下:将具有自动控制温度的低居里温度合金材料加入高分子材料形成具有热疗和栓塞双重治疗作用的热疗栓塞微球,热疗栓塞微球在交变磁场中能升温,实现肿瘤的热疗;并可以自动控制温度。
The invention relates to a temperature controllable thermotherapy plug micro-sphere, magnetic response micro-sphere is scattered in the cross linked net formed by high polymer material; the grain size of the thermotherapy plug is between 50-2000 ª–m, the weight proportion of the magnetic response micro-sphere in the whole plug micro-sphere is 0.5-45%. The preparing method I this invention comprises the following steps: a: adding the metal material into the solution of high polymer material, mixing uniformly to form the solution containing magnetic high polymer material; b: adding the solution containing magnetic high polymer material into the discontinuous phase with stirring; c: preparing the magnetic response polymer micro-sphere; d: filtering, washing and preparing the turbid liquor of the magnetic response micro-sphere; e: preparing dry magnetic response polymer micro-sphere. The good effect of the invention is as follows: adding the low Curie temperature metal material with automatic temperature control into the high polymer material to form the thermotherapy plug micro-sphere with two functions of thermotheraphy and plug, the temperature of the thermotherapy plug micro-sphere will increase in the alternating magnetic field to realize the thermotheraphy to the tumor; the temperature can be controlled automatically.

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    CN-102905733-AJanuary 30, 2013明尼苏达大学董事会Bioresorbable embolization microspheres
    CN-102905733-BOctober 15, 2014明尼苏达大学董事会生物可吸收栓塞微球